Lewis B Silverman Selected Research

Asparaginase (Elspar)

11/2022	Orthopedic toxicities among adolescents and young adults treated in DFCI ALL Consortium Trials.
3/2022	Clinical Characteristics and Short-Term Outcomes of Children With Asparaginase-Associated Pancreatitis.
11/2021	Efficacy and Toxicity of Pegaspargase and Calaspargase Pegol in Childhood Acute Lymphoblastic Leukemia: Results of DFCI 11-001.
1/2020	HLA alleles associated with asparaginase hypersensitivity in childhood ALL: a report from the DFCI Consortium.
1/2019	Trypsin-encoding PRSS1-PRSS2 variations influence the risk of asparaginase-associated pancreatitis in children with acute lymphoblastic leukemia: a Ponte di Legno toxicity working group report.
7/2017	Whole-exome sequencing identified genetic risk factors for asparaginase-related complications in childhood ALL patients.
2/2017	Synergistic Drug Combinations with a CDK4/6 Inhibitor in T-cell Acute Lymphoblastic Leukemia.
1/2017	Asparaginase-associated pancreatitis in childhood acute lymphoblastic leukaemia: an observational Ponte di Legno Toxicity Working Group study.
3/2016	Consensus expert recommendations for identification and management of asparaginase hypersensitivity and silent inactivation.
2/2016	Activity and Toxicity of Intravenous Erwinia Asparaginase Following Allergy to E. coli-Derived Asparaginase in Children and Adolescents With Acute Lymphoblastic Leukemia.

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Lewis B Silverman Research Topics

Disease

78	Precursor Cell Lymphoblastic Leukemia-Lymphoma (Acute Lymphoblastic Leukemia) 10/2022 - 07/2003
34	Neoplasms (Cancer) 01/2022 - 03/2005
21	Leukemia 10/2022 - 02/2003
15	Precursor T-Cell Lymphoblastic Leukemia-Lymphoma (T-ALL) 01/2022 - 07/2003
11	Hypersensitivity (Allergy) 11/2021 - 03/2007
10	Pancreatitis 03/2022 - 03/2007
9	Residual Neoplasm 11/2021 - 07/2003
8	Osteonecrosis (Kienbock's Disease) 11/2022 - 03/2013
6	Cardiotoxicity 12/2014 - 03/2008
5	Infections 01/2020 - 02/2005
4	Thrombosis (Thrombus) 01/2022 - 02/2011
3	Philadelphia Chromosome 01/2022 - 11/2010
3	Cardiomyopathies (Cardiomyopathy) 10/2013 - 10/2010
2	Mucositis 10/2022 - 01/2020
2	Disease Progression 03/2022 - 08/2009
2	Hyperbilirubinemia 11/2021 - 08/2016
2	Capillary Leak Syndrome 01/2021 - 10/2017
2	Abdominal Pain (Pain, Abdominal) 01/2019 - 01/2017
2	Down Syndrome (Down's Syndrome) 10/2018 - 01/2013
2	Fever (Fevers) 01/2017 - 01/2017
2	Peripheral Nervous System Diseases (PNS Diseases) 01/2016 - 06/2014
2	Hodgkin Disease (Hodgkin's Disease) 06/2011 - 03/2008
2	Anaphylaxis (Anaphylactic Shock) 02/2010 - 10/2003
1	Hypokalemia 10/2022
1	Febrile Neutropenia 10/2022
1	Tumor Lysis Syndrome 10/2022
1	Pleural Effusion (Pleural Effusions) 03/2022
1	Metabolic Syndrome (Dysmetabolic Syndrome X) 01/2022
1	Cataract (Cataracts) 01/2022
1	Hyperglycemia 01/2022
1	Chromosome Breakage 01/2019
1	Genetic Predisposition to Disease (Genetic Predisposition) 01/2019

Drug/Important Bio-Agent (IBA)

22	Asparaginase (Elspar)FDA Link 11/2022 - 03/2007
8	Pharmaceutical PreparationsIBA 01/2021 - 11/2007
8	Doxorubicin (Adriamycin)FDA LinkGeneric 02/2017 - 07/2004
7	Adrenal Cortex Hormones (Corticosteroids)IBA 11/2022 - 09/2011
6	DNA (Deoxyribonucleic Acid)IBA 01/2021 - 07/2009
5	pegaspargase (Oncaspar)FDA Link 01/2022 - 02/2010
5	Transcription Factors (Transcription Factor)IBA 12/2018 - 10/2011
5	Dexamethasone (Maxidex)FDA LinkGeneric 10/2017 - 03/2013
5	Methotrexate (Mexate)FDA LinkGeneric 02/2017 - 10/2003
5	Dexrazoxane (Zinecard)FDA LinkGeneric 03/2016 - 07/2004
4	GlucocorticoidsIBA 01/2022 - 02/2017
3	EnzymesIBA 01/2019 - 01/2017
3	Biomarkers (Surrogate Marker)IBA 11/2016 - 04/2012
3	Receptor Protein-Tyrosine Kinases (Tyrosine Kinase Receptors)IBA 08/2016 - 02/2003
3	AnthracyclinesIBA 12/2014 - 03/2008
3	Troponin T (Troponin T1)IBA 10/2013 - 07/2004
2	Cyclophosphamide (Cytoxan)FDA LinkGeneric 10/2022 - 12/2011
2	Etoposide (VP 16)FDA LinkGeneric 10/2022 - 12/2011
2	RNA (Ribonucleic Acid)IBA 01/2022 - 01/2021
2	Insulin (Novolin)FDA Link 01/2022 - 01/2017
2	immunotoxin HA22IBA 01/2021 - 10/2017
2	Biological ProductsIBA 10/2020 - 01/2019
2	Dasatinib (BMS 354825)FDA Link 10/2020 - 01/2018
2	Imatinib Mesylate (Gleevec)FDA Link 10/2020 - 01/2018
2	AntigensIBA 11/2018 - 09/2005
2	Antigen Receptors (Antigen Receptor)IBA 01/2018 - 09/2007
2	Everolimus FDA Link 01/2018 - 02/2017
2	Proteins (Proteins, Gene)FDA Link 11/2017 - 09/2014
2	Aspartate-Ammonia Ligase (Asparagine Synthetase)IBA 01/2015 - 11/2011
2	Lysine (L-Lysine)FDA Link 12/2014 - 11/2008
2	Histones (Histone)IBA 12/2014 - 11/2008
2	Prednisone (Sone)FDA LinkGeneric 11/2013 - 03/2013
2	pro-brain natriuretic peptide (1-76)IBA 10/2013 - 04/2012
2	Brain Natriuretic Peptide (Natrecor)FDA Link 10/2013 - 04/2012
1	Phosphatidylinositol 3-Kinase (1 Phosphatidylinositol 3 Kinase)IBA 10/2022
1	Alanine Transaminase (SGPT)IBA 10/2022
1	temsirolimus FDA Link 10/2022
1	TOR Serine-Threonine KinasesIBA 10/2022
1	antiarrhythmic peptide (AAP)IBA 03/2022
1	Mitogen-Activated Protein Kinase Kinases (MEKs)IBA 01/2022
1	tofacitinibIBA 01/2022
1	Glucose (Dextrose)FDA LinkGeneric 01/2022
1	Blood Group Antigens (Blood Groups)IBA 01/2022
1	calaspargase pegolIBA 11/2021
1	Small Cytoplasmic RNAIBA 01/2021
1	Tyrosine Kinase InhibitorsIBA 10/2020
1	AntioxidantsIBA 01/2020
1	HLA Antigens (Human Leukocyte Antigens)IBA 01/2020
1	HLA-DRB1 Chains (HLA DRB1)IBA 01/2020
1	HLA-DRB1*07 antigenIBA 01/2020
1	HLA-DQB1 antigen (HLA DQB1)IBA 01/2020
1	HLA-DQA1 antigen (HLA DQA1)IBA 01/2020
1	Chimeric Antigen ReceptorsIBA 12/2019
1	TrypsinogenIBA 01/2019
1	Bcl-2-Like Protein 11IBA 01/2019
1	TrypsinIBA 01/2019
1	Polycomb Repressive Complex 2IBA 12/2018
1	ChromatinIBA 11/2018

Therapy/Procedure

49	Therapeutics 01/2022 - 07/2003
22	Drug Therapy (Chemotherapy) 01/2022 - 07/2004
3	Induction Chemotherapy 01/2022 - 08/2010
3	Radiotherapy 03/2016 - 07/2004
3	Hematopoietic Stem Cell Transplantation 01/2013 - 10/2010
2	Cranial Irradiation 01/2018 - 09/2009
2	Remission Induction 04/2012 - 02/2010
1	Cell Transplantation 01/2019
1	Injections 01/2019
1	Homologous Transplantation 01/2019